TGFB1I1

Across TCGA patient cohorts, TGFB1I1 mutation is significantly associated with the RNA expression of many other genes, with 1,700 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGFB1I1-associated genes across cancer lineages are RN7SL447P, RN7SL472P, and RNA5SP394. Each is linked with TGFB1I1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TGFB1I1-to-partner and partner-to-TGFB1I1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL447P grouped by TGFB1I1-low versus TGFB1I1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGFB1I1→partner) and Y-score (partner→TGFB1I1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL447P →	+0.142	+4.201	<.001	.002	3	3
SKCM	RN7SL472P →	+0.590	+3.513	<.001	<.001	3	2
CESC	RNA5SP394 →	+0.244	+3.760	<.001	.004	3	2
CESC	RNU6-886P →	+0.409	+3.735	<.001	.003	3	2
CESC	RNA5SP198 →	+0.198	+4.144	<.001	.009	3	2
CESC	RNU6-1100P →	+0.359	+5.569	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,700 associations by consensus.

RN7SL447P by TGFB1I1 expression — CESC

Explore this box plot interactively →