TGFB1

Across TCGA patient cohorts, TGFB1 mutation is significantly associated with the RNA expression of many other genes, with 435 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGFB1-associated genes across cancer lineages are C2orf83, IGHD2-2, and RN7SL470P. Each is linked with TGFB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TGFB1-to-partner and partner-to-TGFB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C2orf83 grouped by TGFB1-low versus TGFB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGFB1→partner) and Y-score (partner→TGFB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C2orf83 →	+0.108	+2.529	.008	.005	3	2
UCEC	IGHD2-2 →	+1.803	+2.457	<.001	.005	3	2
UCEC	RN7SL470P →	+0.249	+2.431	.001	.009	3	2
HNSC	SEPTIN14P19 →	+0.056	+4.822	<.001	.006	3	1
BRCA	RNU6-1258P →	+0.322	+8.471	<.001	.005	3	1
BRCA	LINC02729 →	+0.079	+7.731	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 435 associations by consensus.

C2orf83 by TGFB1 expression — UCEC

Explore this box plot interactively →