TGDS

Across TCGA patient cohorts, TGDS RNA expression is significantly associated with the protein abundance of many other proteins, with 9,336 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible TGDS-associated proteins across cancer lineages are RBM26, CUL4A, and DIS3. Each is linked with TGDS in more than 5 cancer types. Because this analysis shows association rather than direction, both TGDS-to-partner and partner-to-TGDS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TGDS versus RBM26 in HNSC, with a Pearson correlation of 0.30.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TGDS→partner) and Y-score (partner→TGDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RBM26 →	+0.295	+0.670	<.001	<.001	3	6
LSCC	CUL4A →	+0.338	+0.423	<.001	<.001	3	6
LSCC	DIS3 →	+0.390	+0.552	<.001	<.001	3	6
OV	MBNL2 →	+0.573	+0.724	<.001	<.001	3	5
LSCC	IPO5 →	+0.306	+0.541	<.001	<.001	3	5
BRCA	ARHGEF7 →	+0.255	+0.621	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,336 associations by consensus.

TGDS vs RBM26 — HNSC

Explore this scatter interactively →