TGDS

Across TCGA pan-cancer cohorts, TGDS RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TGDS’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TGDS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TGDS is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, BLCA, and COAD are the cancer types where TGDS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TGDS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.677	<.001	12	view →
BLCA	Male	All	+0.655	<.001	11	view →
COAD	Male	III,IV	+1.509	<.001	10	view →
THCA	All	All	−0.296	<.001	9	view →
KICH	Female	II,III,IV	−1.591	<.001	8	view →
LUAD	Male	All	+0.579	<.001	8	view →
KIRC	All	All	+0.272	<.001	8	view →
STAD	Female	All	+1.070	<.001	7	view →
READ	All	II,III,IV	+1.240	.001	5	view →
BRCA	All	All	−0.252	<.001	4	view →
UCEC	All	IV	−1.605	.045	2	view →
ESCA	All	All	+0.973	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TGDS–HNSC

Open the HNSC breakdown →