TGDS

Across TCGA patient cohorts, TGDS mutation is significantly associated with the RNA expression of many other genes, with 564 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGDS-associated genes across cancer lineages are BTG3P1, MIR4473, and RNU6-839P. Each is linked with TGDS in more than 1 cancer types. Because this analysis shows association rather than direction, both TGDS-to-partner and partner-to-TGDS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BTG3P1 grouped by TGDS-low versus TGDS-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGDS→partner) and Y-score (partner→TGDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	BTG3P1 →	+0.089	+7.816	<.001	.008	3	2
LUSC	MIR4473 →	+0.447	+5.474	<.001	.005	3	2
SKCM	RNU6-839P →	+0.458	+7.816	<.001	.008	3	2
STAD	RNU6-940P →	+0.447	+5.105	<.001	.008	3	2
SKCM	MRPS5P4 →	+0.139	+7.816	<.001	.008	3	2
SKCM	H2AB3 →	+0.109	+7.816	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 564 associations by consensus.

BTG3P1 by TGDS expression — SKCM

Explore this box plot interactively →