TGDS

Across TCGA patient cohorts, TGDS mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGDS-associated genes across cancer lineages are EGFR_pY1068, GATA6, and ACVRL1. Each is linked with TGDS in more than 1 cancer types. Because this analysis shows association rather than direction, both TGDS-to-partner and partner-to-TGDS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TGDS-low versus TGDS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGDS→partner) and Y-score (partner→TGDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.410	-3.321	<.001	.009	3	1
UCEC	GATA6 →	-0.205	-3.577	.006	.002	3	1
UCEC	ACVRL1 →	-0.193	-3.150	.003	.019	3	1
UCEC	JNK2 →	+0.278	+3.331	.003	.005	3	1
UCEC	mTOR_pS2448 →	-0.161	-2.459	.025	.020	3	1
UCEC	Annexin-1 →	+0.856	+3.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

EGFR_pY1068 by TGDS expression — UCEC

Explore this box plot interactively →