TGDS

Across TCGA cell cohorts, TGDS mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TGDS-associated genes across cancer lineages are C10orf53, GSG1L2, and MYT1L. Each is linked with TGDS in more than 1 cancer types. Because this analysis shows association rather than direction, both TGDS-to-partner and partner-to-TGDS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C10orf53 grouped by TGDS-low versus TGDS-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGDS→partner) and Y-score (partner→TGDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C10orf53 →	+0.013	+3.217	<.001	.006	3	1
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1
LARGE_INTESTINE	MYT1L →	+0.160	+3.333	.006	.009	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

C10orf53 by TGDS expression — LARGE_INTESTINE

Explore this box plot interactively →