TFPI2-DT

Across TCGA pan-cancer cohorts, TFPI2-DT RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TFPI2-DT data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TFPI2-DT RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TFPI2-DT expression acts as an unfavorable survival marker, although some lineages such as MESO and UCS show a favorable association.

COAD, UVM, and STAD are the cancer types where TFPI2-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.384	0.607	<.001	111	view →
UVM	DFS	Tertile	All	0.364	0.864	.001	75	view →
STAD	OS	Tertile	All	0.583	0.722	.003	61	view →
ACC	OS	Tertile	All	0.756	0.966	.001	47	view →
MESO	OS	Quartile	IV	0.951	0.399	.002	43	view →
UCS	DFS	Quartile	II,III,IV	0.634	0.181	.002	38	view →
THCA	DFS	Tertile	II,III,IV	0.517	0.753	.006	33	view →
CESC	OS	Tertile	All	0.814	0.920	.004	28	view →
OV	DFS	Quartile	II,III,IV	0.140	0.209	.021	28	view →
LIHC	DFS	Quartile	All	0.405	0.594	.001	25	view →
ESCA	OS	Quartile	All	1.000	0.323	.009	19	view →
LUAD	OS	Median	All	0.255	0.470	.014	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TFPI2-DT–COAD (DFS)

Open the COAD breakdown →