TFPI2-DT

Across TCGA pan-cancer cohorts, TFPI2-DT RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TFPI2-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TFPI2-DT RNA is repressed in tumor relative to normal tissue. In most cancer types TFPI2-DT is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KICH, HNSC, and LUAD are the cancer types where TFPI2-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TFPI2-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−1.588	<.001	11	view →
HNSC	Male	II,III,IV	+0.774	<.001	11	view →
LUAD	Male	All	+0.844	<.001	8	view →
LUSC	Male	All	+0.867	<.001	6	view →
KIRP	All	All	+0.856	<.001	6	view →
KIRC	All	IV	+0.462	.002	6	view →
ESCA	All	II,III,IV	+1.250	.012	4	view →
BLCA	All	All	+0.369	.029	4	view →
STAD	All	All	+0.363	.006	4	view →
COAD	All	All	+0.160	.002	4	view →
UCEC	All	All	+0.584	<.001	2	view →
CHOL	Female	All	+0.329	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TFPI2-DT–KICH

Open the KICH breakdown →