TFPI

Across TCGA patient cohorts, TFPI protein abundance is significantly associated with the RNA expression of many other genes, with 7,268 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TFPI-associated genes across cancer lineages are KCNJ8, TMEM97, and LYVE1. Each is linked with TFPI in more than 4 cancer types. Because this analysis shows association rather than direction, both TFPI-to-partner and partner-to-TFPI results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TFPI versus KCNJ8 in BRCA, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFPI→partner) and Y-score (partner→TFPI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KCNJ8 →	+0.859	+0.691	<.001	<.001	3	5
LSCC	TMEM97 →	-1.031	-0.575	<.001	<.001	3	4
BRCA	LYVE1 →	+1.196	+0.535	<.001	.006	3	4
UCEC	HECW2 →	+0.548	+0.829	<.001	<.001	3	4
BRCA	DIPK2B →	+0.772	+0.599	<.001	<.001	3	4
LSCC	ESAM →	+0.697	+0.472	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,268 associations by consensus.

TFPI vs KCNJ8 — BRCA

Explore this scatter interactively →