TFPI

Across TCGA pan-cancer cohorts, TFPI RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TFPI data layer compared with 8 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher TFPI RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TFPI expression acts as an unfavorable survival marker, although some lineages such as PRAD and READ show a favorable association.

STAD, LUAD, and LGG are the cancer types where TFPI RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Tertile	All	0.295	0.519	.001	69	view →
LUAD	OS	Median	III,IV	0.333	0.653	.002	62	view →
LGG	DFS	Median	All	0.656	0.828	<.001	54	view →
CESC	OS	Quartile	IV	0.137	0.619	.001	52	view →
LUSC	DFS	Quartile	II,III,IV	0.257	0.473	.007	45	view →
PRAD	DFS	Quartile	All	0.894	0.678	.011	16	view →
SCLC	OS	Median	II,III,IV	0.477	1.000	.012	15	view →
CHOL	DFS	Tertile	All	0.260	0.701	.006	15	view →
THCA	OS	Tertile	II,III,IV	0.960	1.000	.011	15	view →
PAAD	DFS	Tertile	All	0.397	0.576	.005	15	view →
UCS	OS	Median	II,III,IV	0.428	0.763	.009	12	view →
READ	OS	Median	III,IV	0.681	0.268	.003	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TFPI–STAD (DFS)

Open the STAD breakdown →