TFPI

Across TCGA cell cohorts, TFPI RNA expression is significantly associated with the go_rna of many other GO terms, with 4,474 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TFPI-associated GO terms across cancer lineages are Oncostatin-M-mediated signaling pathway, Branching involved in blood vessel morphogenesis, and Death-inducing signaling complex assembly. Each is linked with TFPI in more than 13 cancer types. Because this analysis shows association rather than direction, both TFPI-to-partner and partner-to-TFPI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Oncostatin-M-mediated signaling pathway grouped by TFPI-low versus TFPI-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TFPI→partner) and Y-score (partner→TFPI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Oncostatin-M-mediated signaling pathway →	+0.199	+4.619	<.001	<.001	2	14
BONE	Branching involved in blood vessel morphogenesis →	+0.260	+1.883	.005	.001	3	11
SOFT_TISSUE	Death-inducing signaling complex assembly →	+0.218	+2.220	.005	<.001	3	11
SOFT_TISSUE	Positive regulation of canonical NF-kappaB signal transduction →	+0.053	+2.849	<.001	<.001	3	10
OVARY	Epithelial cell fate commitment →	+0.174	+3.378	<.001	<.001	3	10
CNS	Regulation of protein monoubiquitination →	+0.140	+2.401	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,474 associations by consensus.

Oncostatin-M-mediated signaling pathway by TFPI expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →