TFPI

Across TCGA cell cohorts, TFPI mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TFPI-associated genes across cancer lineages are IQCF6 and CD300H. Each is linked with TFPI in more than 1 cancer types. Because this analysis shows association rather than direction, both TFPI-to-partner and partner-to-TFPI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF6 grouped by TFPI-low versus TFPI-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFPI→partner) and Y-score (partner→TFPI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IQCF6 →	+0.311	+4.467	<.001	.004	3	1
LARGE_INTESTINE	CD300H →	+0.033	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

IQCF6 by TFPI expression — LARGE_INTESTINE

Explore this box plot interactively →