TFIP11

Across TCGA patient cohorts, TFIP11 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TFIP11-associated genes across cancer lineages are FOXO3a_pS318_S321, GAPDH, and Lck. Each is linked with TFIP11 in more than 1 cancer types. Because this analysis shows association rather than direction, both TFIP11-to-partner and partner-to-TFIP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by TFIP11-low versus TFIP11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFIP11→partner) and Y-score (partner→TFIP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.116	-2.312	.010	.005	3	2
UCEC	GAPDH →	+0.413	+2.700	.032	.005	3	2
UCEC	Lck →	+0.178	+2.999	.013	.035	3	2
UCEC	MEK1 →	+0.419	+2.087	.001	.005	3	2
UCEC	MSH2 →	-0.359	-2.896	<.001	.001	3	2
UCEC	MSH6 →	-0.463	-2.797	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

FOXO3a_pS318_S321 by TFIP11 expression — UCEC

Explore this box plot interactively →