TFIP11

Across TCGA cell cohorts, TFIP11 mutation is significantly associated with the RNA expression of many other genes, with 114 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TFIP11-associated genes across cancer lineages are PPP3R2, TSPAN16, and LRRC3B. Each is linked with TFIP11 in more than 1 cancer types. Because this analysis shows association rather than direction, both TFIP11-to-partner and partner-to-TFIP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP3R2 grouped by TFIP11-low versus TFIP11-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFIP11→partner) and Y-score (partner→TFIP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPP3R2 →	+0.026	+2.337	.001	.002	3	2
OESOPHAGUS	TSPAN16 →	+0.040	+4.432	<.001	<.001	3	1
OESOPHAGUS	LRRC3B →	+0.057	+3.392	<.001	.007	3	1
OESOPHAGUS	GAGE2A →	+2.945	+3.652	<.001	.006	3	1
LARGE_INTESTINE	KLHL2 →	+0.762	+3.502	<.001	.001	3	1
LARGE_INTESTINE	C12orf57 →	+0.948	+3.321	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 114 associations by consensus.

PPP3R2 by TFIP11 expression — LARGE_INTESTINE

Explore this box plot interactively →