TFEC

Across TCGA patient cohorts, TFEC mutation is significantly associated with the RNA expression of many other genes, with 3,466 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TFEC-associated genes across cancer lineages are RNU7-90P, UHRF1, and CEP57L1. Each is linked with TFEC in more than 2 cancer types. Because this analysis shows association rather than direction, both TFEC-to-partner and partner-to-TFEC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-90P grouped by TFEC-low versus TFEC-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFEC→partner) and Y-score (partner→TFEC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU7-90P →	+0.328	+3.266	.001	.009	3	3
UCEC	UHRF1 →	+0.943	+2.180	<.001	.002	3	2
SKCM	CEP57L1 →	+0.460	+2.090	<.001	<.001	3	2
UCEC	KMT5A →	+0.473	+2.673	<.001	<.001	3	2
SKCM	RPL23AP82 →	+0.441	+2.870	<.001	.001	3	2
UCEC	UBE2L3 →	+0.339	+3.815	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,466 associations by consensus.

RNU7-90P by TFEC expression — BLCA

Explore this box plot interactively →