TFEC

Across TCGA pan-cancer cohorts, TFEC RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TFEC’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TFEC RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TFEC is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

KIRC, HNSC, and LUSC are the cancer types where TFEC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TFEC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	+1.542	<.001	10	view →
HNSC	Female	II,III,IV	+0.707	<.001	9	view →
LUSC	Male	II,III,IV	−1.453	<.001	8	view →
LUAD	Female	III,IV	−1.076	<.001	8	view →
KICH	All	II,III,IV	−1.789	<.001	7	view →
STAD	All	II,III,IV	+0.850	<.001	7	view →
BRCA	Female	II,III,IV	+0.645	<.001	6	view →
THCA	Male	II,III,IV	+0.431	.026	3	view →
PAAD	All	All	−1.772	.014	2	view →
ESCA	All	All	+0.686	.033	1	view →
CHOL	All	All	+0.686	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TFEC–KIRC

Open the KIRC breakdown →