TFEC

Across TCGA patient cohorts, TFEC mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TFEC-associated genes across cancer lineages are ERCC1, ASNS, and PDCD4. Each is linked with TFEC in more than 1 cancer types. Because this analysis shows association rather than direction, both TFEC-to-partner and partner-to-TFEC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERCC1 grouped by TFEC-low versus TFEC-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFEC→partner) and Y-score (partner→TFEC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ERCC1 →	+0.138	+1.824	.039	.015	3	2
SKCM	ASNS →	+0.354	+3.321	.046	.009	3	2
UCEC	PDCD4 →	-0.452	-2.312	.019	.034	3	2
UCEC	Shc_pY317 →	-0.188	-2.321	.002	.006	3	2
SKCM	ACC1 →	+0.254	+3.169	.046	.017	3	1
SKCM	E-Cadherin →	-0.809	-3.000	.024	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

ERCC1 by TFEC expression — SKCM

Explore this box plot interactively →