TFEC

Across TCGA cell cohorts, TFEC RNA expression is significantly associated with the go_rna of many other GO terms, with 1,780 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TFEC-associated GO terms across cancer lineages are Presynaptic endocytosis, Regulation of ferroptosis, and Positive regulation of protein catabolic process in the vacuole. Each is linked with TFEC in more than 4 cancer types. Because this analysis shows association rather than direction, both TFEC-to-partner and partner-to-TFEC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Presynaptic endocytosis grouped by TFEC-low versus TFEC-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TFEC→partner) and Y-score (partner→TFEC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Presynaptic endocytosis →	+0.049	+0.169	<.001	.005	3	5
BLOOD_Leukemia	Regulation of ferroptosis →	+0.104	+2.150	<.001	<.001	3	4
BLOOD_Leukemia	Positive regulation of protein catabolic process in the vacuole →	+0.083	+1.651	<.001	<.001	3	4
BLOOD_Leukemia	Regulation of cell-matrix adhesion →	+0.039	+1.344	.002	.004	2	5
BLOOD_Leukemia	Regulation of entry of bacterium into host cell →	+0.092	+1.824	<.001	<.001	3	4
BLOOD_Leukemia	Positive regulation of translational initiation →	+0.068	+2.505	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,780 associations by consensus.

Presynaptic endocytosis by TFEC expression — CNS

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