TFE3

Across TCGA patient cohorts, TFE3 protein abundance is significantly associated with the RNA expression of many other genes, with 7,553 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TFE3-associated genes across cancer lineages are GOLGA8UP, SQSTM1, and GPX1. Each is linked with TFE3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TFE3-to-partner and partner-to-TFE3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TFE3 versus GOLGA8UP in GBM, with a Pearson correlation of -0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFE3→partner) and Y-score (partner→TFE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GOLGA8UP →	-0.948	-0.390	<.001	<.001	3	3
LSCC	SQSTM1 →	+0.620	+0.272	.001	<.001	3	3
GBM	GPX1 →	+0.470	+0.263	.001	<.001	3	3
LUAD	USP27X →	+0.877	+0.187	.002	.006	3	3
GBM	MSR1 →	+0.753	+0.270	.002	<.001	3	3
PDAC	CD300E →	+0.866	+0.357	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,553 associations by consensus.

TFE3 vs GOLGA8UP — GBM

Explore this scatter interactively →