TFE3

Across TCGA patient cohorts, TFE3 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TFE3-associated genes across cancer lineages are INPP4B, p62 Lck ligand, and Tuberin. Each is linked with TFE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TFE3-to-partner and partner-to-TFE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by TFE3-low versus TFE3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFE3→partner) and Y-score (partner→TFE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.303	-1.847	.003	.007	3	2
UCEC	p62 Lck ligand →	+0.263	+2.906	.011	.001	3	2
UCEC	Tuberin →	+0.238	+1.777	.005	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.982	+4.247	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.074	-1.558	.021	.032	3	1
UCEC	eEF2 →	+0.352	+1.289	.002	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

INPP4B by TFE3 expression — UCEC

Explore this box plot interactively →