TFE3

Across TCGA cell cohorts, TFE3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,506 significant associations in total. CNS shows the largest number of these associations.

The most reproducible TFE3-associated GO terms across cancer lineages are Growth hormone secretion, Type 2 mitophagy, and Post-Golgi vesicle-mediated transport. Each is linked with TFE3 in more than 15 cancer types. Because this analysis shows association rather than direction, both TFE3-to-partner and partner-to-TFE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Growth hormone secretion grouped by TFE3-low versus TFE3-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TFE3→partner) and Y-score (partner→TFE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Growth hormone secretion →	+0.125	+0.775	<.001	<.001	3	16
BONE	Type 2 mitophagy →	+0.221	+1.099	<.001	<.001	3	16
STOMACH	Post-Golgi vesicle-mediated transport →	+0.085	+0.965	.002	.009	2	16
STOMACH	Golgi to plasma membrane protein transport →	+0.153	+1.274	<.001	<.001	3	15
BONE	Vesicle-mediated transport to the plasma membrane →	+0.098	+1.360	<.001	<.001	3	14
BONE	Actin filament depolymerization →	+0.146	+0.832	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,506 associations by consensus.

Growth hormone secretion by TFE3 expression — OESOPHAGUS

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