TFE3

Across TCGA cell cohorts, TFE3 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TFE3-associated genes across cancer lineages are ADH1A, CCDC182, and ACSM2A. Each is linked with TFE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TFE3-to-partner and partner-to-TFE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADH1A grouped by TFE3-low versus TFE3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFE3→partner) and Y-score (partner→TFE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADH1A →	+0.172	+2.657	<.001	.007	3	1
OVARY	CCDC182 →	+0.081	+4.700	<.001	.002	3	1
OVARY	ACSM2A →	+0.045	+4.029	.006	.009	3	1
BLOOD_Leukemia	TACR3 →	+0.034	+4.060	<.001	.003	3	1
BLOOD_Leukemia	PRND →	+0.009	+3.874	<.001	.005	3	1
BLOOD_Leukemia	VWC2L →	+0.012	+4.339	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ADH1A by TFE3 expression — LARGE_INTESTINE

Explore this box plot interactively →