TFCP2L1

Across TCGA patient cohorts, TFCP2L1 mutation is significantly associated with the RNA expression of many other genes, with 1,644 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TFCP2L1-associated genes across cancer lineages are USP9YP10, RNA5SP459, and NEDD8-MDP1. Each is linked with TFCP2L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TFCP2L1-to-partner and partner-to-TFCP2L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP9YP10 grouped by TFCP2L1-low versus TFCP2L1-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFCP2L1→partner) and Y-score (partner→TFCP2L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	2
LGG	RNA5SP459 →	+0.278	+7.977	<.001	.007	3	2
SKCM	NEDD8-MDP1 →	+0.133	+1.861	.002	.007	3	2
SKCM	PGDP1 →	+0.081	+2.367	<.001	.004	3	2
SKCM	TYMSP2 →	+0.047	+2.158	<.001	.007	3	2
SKCM	MIR212 →	+0.091	+3.556	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,644 associations by consensus.

USP9YP10 by TFCP2L1 expression — LGG

Explore this box plot interactively →