TFB2M

Across TCGA cell cohorts, TFB2M mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TFB2M-associated genes across cancer lineages are MAGEB5, PIRT, and OR10W1. Each is linked with TFB2M in more than 1 cancer types. Because this analysis shows association rather than direction, both TFB2M-to-partner and partner-to-TFB2M results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by TFB2M-low versus TFB2M-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFB2M→partner) and Y-score (partner→TFB2M) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	PIRT →	+0.006	+4.643	<.001	.008	3	1
LARGE_INTESTINE	OR10W1 →	+0.022	+4.977	<.001	.007	3	1
BLOOD_Leukemia	PHOX2B →	+0.022	+4.365	<.001	.002	3	1
BLOOD_Leukemia	STATH →	+0.415	+4.133	<.001	.003	3	1
BLOOD_Leukemia	OR11H1 →	+0.063	+4.786	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

MAGEB5 by TFB2M expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →