TFB2M

Across TCGA pan-cancer cohorts, TFB2M RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of TFB2M’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where TFB2M RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TFB2M is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

LUAD, THCA, and BLCA are the cancer types where TFB2M tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TFB2M RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	+1.273	<.001	9	view →
THCA	All	IV	−1.054	<.001	9	view →
BLCA	All	III,IV	+0.915	<.001	9	view →
COAD	Male	II,III,IV	+0.683	<.001	9	view →
LUSC	Male	II,III,IV	+1.226	<.001	8	view →
STAD	Male	II,III,IV	+0.915	<.001	8	view →
HNSC	Male	III,IV	+0.836	<.001	8	view →
KICH	Female	All	−1.230	<.001	7	view →
LIHC	Male	All	+0.939	<.001	6	view →
BRCA	All	II,III,IV	+0.857	<.001	6	view →
KIRC	Male	All	−0.362	<.001	6	view →
CHOL	All	All	+0.993	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

TFB2M–LUAD

Open the LUAD breakdown →