TFAP4

Across TCGA cell cohorts, TFAP4 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TFAP4-associated genes across cancer lineages are USP17L15, CLDN17, and RIPPLY2. Each is linked with TFAP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TFAP4-to-partner and partner-to-TFAP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP17L15 grouped by TFAP4-low versus TFAP4-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFAP4→partner) and Y-score (partner→TFAP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	USP17L15 →	+0.136	+4.906	<.001	.006	3	1
LARGE_INTESTINE	CLDN17 →	+0.052	+3.930	.001	.003	3	1
LARGE_INTESTINE	RIPPLY2 →	+0.609	+4.196	<.001	.002	3	1
LARGE_INTESTINE	OR2J3 →	+0.044	+3.920	<.001	.005	3	1
LARGE_INTESTINE	OR5V1 →	+0.008	+4.437	<.001	.004	3	1
LARGE_INTESTINE	MYOC →	+0.032	+3.807	<.001	.006	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

USP17L15 by TFAP4 expression — OESOPHAGUS

Explore this box plot interactively →