TFAP2E-AS1

Across TCGA pan-cancer cohorts, TFAP2E-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated TFAP2E-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TFAP2E-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TFAP2E-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and LUAD are the cancer types where TFAP2E-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.442	0.266	<.001	144	view →
SKCM	DFS	Median	All	0.678	0.556	<.001	119	view →
LUAD	OS	Tertile	All	0.786	0.594	<.001	63	view →
CESC	DFS	Tertile	All	0.715	0.438	<.001	62	view →
KIRC	OS	Quartile	All	0.573	0.765	<.001	34	view →
ACC	OS	Median	II,III,IV	0.675	0.964	.007	23	view →
LGG	DFS	Median	All	0.279	0.473	<.001	22	view →
THYM	OS	Median	II,III,IV	0.962	0.682	.003	18	view →
PRAD	DFS	Median	All	0.834	0.928	<.001	18	view →
UCEC	OS	Quartile	III,IV	0.864	0.768	.022	16	view →
THCA	DFS	Tertile	All	0.896	0.766	.017	12	view →
DLBC	OS	Median	II,III,IV	0.305	1.000	.015	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

TFAP2E-AS1–HNSC (DFS)

Open the HNSC breakdown →