TFAP2E-AS1

Across TCGA pan-cancer cohorts, TFAP2E-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TFAP2E-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TFAP2E-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TFAP2E-AS1 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, THCA, and LUAD are the cancer types where TFAP2E-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TFAP2E-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.794	<.001	12	view →
THCA	Female	II,III,IV	+0.951	<.001	11	view →
LUAD	Female	II,III,IV	−0.852	<.001	9	view →
HNSC	All	All	+0.327	<.001	9	view →
LUSC	Male	II,III,IV	−0.706	<.001	6	view →
KICH	Female	All	−0.470	<.001	6	view →
STAD	Female	All	+0.670	.001	4	view →
UCEC	All	All	−0.227	.036	4	view →
CHOL	All	All	+0.764	.001	2	view →
BRCA	All	III,IV	−0.267	.017	2	view →
ESCA	Male	All	+0.626	.020	1	view →
KIRP	Male	All	+0.411	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TFAP2E-AS1–KIRC

Open the KIRC breakdown →