TFAP2D

Across TCGA patient cohorts, TFAP2D mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TFAP2D-associated genes across cancer lineages are Cyclin-B1, Bim, and Syk. Each is linked with TFAP2D in more than 3 cancer types. Because this analysis shows association rather than direction, both TFAP2D-to-partner and partner-to-TFAP2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by TFAP2D-low versus TFAP2D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFAP2D→partner) and Y-score (partner→TFAP2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.641	+2.906	<.001	.001	3	4
COAD	Bim →	+0.275	+3.593	.019	.001	3	4
LUAD	Syk →	+0.288	+2.321	.025	.033	3	4
COAD	PCNA →	+0.252	+2.820	.019	.035	3	3
COAD	Shc_pY317 →	-0.191	-3.157	.008	.018	3	3
LUAD	A-Raf_pS299 →	-0.219	-3.000	.043	.034	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Cyclin-B1 by TFAP2D expression — UCEC

Explore this box plot interactively →