TFAP2D

Across TCGA pan-cancer cohorts, TFAP2D RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TFAP2D’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where TFAP2D RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TFAP2D is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

LUAD, LUSC, and BRCA are the cancer types where TFAP2D tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TFAP2D RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	+0.980	<.001	4	view →
LUSC	All	All	+0.133	.004	2	view →
BRCA	Female	All	−0.011	.015	2	view →
KICH	All	II,III,IV	−0.010	.037	2	view →
THCA	All	All	−0.027	.028	1	view →
KIRC	All	All	+0.003	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TFAP2D–LUAD

Open the LUAD breakdown →