TFAP2D

Across TCGA cell cohorts, TFAP2D mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TFAP2D-associated genes across cancer lineages are KRT28, KRTAP21-1, and SLC22A25. Each is linked with TFAP2D in more than 1 cancer types. Because this analysis shows association rather than direction, both TFAP2D-to-partner and partner-to-TFAP2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT28 grouped by TFAP2D-low versus TFAP2D-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFAP2D→partner) and Y-score (partner→TFAP2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	KRT28 →	+0.044	+3.459	<.001	.006	3	1
LUNG_NSCLC_LUAD	KRTAP21-1 →	+0.025	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	SLC22A25 →	+0.155	+4.371	<.001	.005	3	1
OVARY	KLHL40 →	+0.011	+4.450	<.001	.004	3	1
OVARY	RBMY1J →	+0.017	+4.807	<.001	.003	3	1
SKIN	MTNR1B →	+0.039	+3.684	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

KRT28 by TFAP2D expression — CNS

Explore this box plot interactively →