TFAP2A

Across TCGA patient cohorts, TFAP2A mutation is significantly associated with the RNA expression of many other genes, with 2,541 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TFAP2A-associated genes across cancer lineages are POLE2, CDT1, and CDCA4. Each is linked with TFAP2A in more than 2 cancer types. Because this analysis shows association rather than direction, both TFAP2A-to-partner and partner-to-TFAP2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLE2 grouped by TFAP2A-low versus TFAP2A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFAP2A→partner) and Y-score (partner→TFAP2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	POLE2 →	+0.570	+3.625	.003	.001	3	3
UCEC	CDT1 →	+0.711	+2.082	<.001	<.001	3	3
UCEC	CDCA4 →	+0.378	+2.086	.004	<.001	3	3
UCEC	MRTO4 →	+0.400	+3.258	<.001	<.001	3	3
UCEC	TXNL4A →	+0.317	+1.850	.002	<.001	3	3
BLCA	RNU6-27P →	+0.290	+4.562	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,541 associations by consensus.

POLE2 by TFAP2A expression — COAD

Explore this box plot interactively →