TFAP2A

Across TCGA patient cohorts, TFAP2A mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TFAP2A-associated genes across cancer lineages are p38-MAPK_pT180_Y182, PCNA, and EGFR_pY1068. Each is linked with TFAP2A in more than 1 cancer types. Because this analysis shows association rather than direction, both TFAP2A-to-partner and partner-to-TFAP2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by TFAP2A-low versus TFAP2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFAP2A→partner) and Y-score (partner→TFAP2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.397	-2.502	.006	.001	3	2
UCEC	PCNA →	+0.233	+1.765	<.001	.013	3	2
UCEC	EGFR_pY1068 →	-0.240	-2.000	.003	<.001	3	1
UCEC	EGFR →	-0.155	-2.674	.002	.005	3	1
UCEC	eIF4E →	+0.156	+2.662	.022	<.001	3	1
UCEC	A-Raf_pS299 →	-0.114	-2.247	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

p38-MAPK_pT180_Y182 by TFAP2A expression — UCEC

Explore this box plot interactively →