TFAP2A

Across TCGA cell cohorts, TFAP2A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,007 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TFAP2A-associated GO terms across cancer lineages are Oculomotor nerve development, Embryonic camera-type eye formation, and Cellular response to iron ion. Each is linked with TFAP2A in more than 18 cancer types. Because this analysis shows association rather than direction, both TFAP2A-to-partner and partner-to-TFAP2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Oculomotor nerve development grouped by TFAP2A-low versus TFAP2A-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TFAP2A→partner) and Y-score (partner→TFAP2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Oculomotor nerve development →	+1.508	+2.727	<.001	<.001	3	19
LARGE_INTESTINE	Embryonic camera-type eye formation →	+0.555	+1.857	.007	.001	3	8
LUNG_SCLC	Cellular response to iron ion →	-0.181	-2.027	<.001	<.001	3	8
LUNG_SCLC	Optic cup morphogenesis involved in camera-type eye development →	+0.254	+1.325	.007	.002	3	8
BLOOD_Lymphoma	Trigeminal nerve development →	+0.666	+1.028	.005	.004	2	8
SKIN	Vacuolar transport →	+0.039	+0.910	.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,007 associations by consensus.

Oculomotor nerve development by TFAP2A expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →