TFAP2A

Across TCGA cell cohorts, TFAP2A mutation is significantly associated with the RNA expression of many other genes, with 117 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TFAP2A-associated genes across cancer lineages are REG1B, PCARE, and MAGEB4. Each is linked with TFAP2A in more than 1 cancer types. Because this analysis shows association rather than direction, both TFAP2A-to-partner and partner-to-TFAP2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by TFAP2A-low versus TFAP2A-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFAP2A→partner) and Y-score (partner→TFAP2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	REG1B →	+0.083	+4.415	<.001	.007	3	1
LUNG_NSCLC_LUAD	PCARE →	+0.040	+4.343	<.001	.002	3	1
LARGE_INTESTINE	MAGEB4 →	+0.009	+3.192	<.001	.002	3	1
LARGE_INTESTINE	RFPL3 →	+0.038	+2.510	<.001	.004	3	1
LARGE_INTESTINE	MS4A3 →	+0.058	+3.647	.007	.001	3	1
LARGE_INTESTINE	SEPTIN14 →	+0.005	+2.514	.007	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 117 associations by consensus.

REG1B by TFAP2A expression — SKIN

Explore this box plot interactively →