TFAP2A-AS1

Across TCGA pan-cancer cohorts, TFAP2A-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TFAP2A-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TFAP2A-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TFAP2A-AS1 expression acts as an unfavorable survival marker, although some lineages such as UVM and UCEC show a favorable association.

KIRC, KIRP, and UVM are the cancer types where TFAP2A-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.529	0.717	<.001	156	view →
KIRP	DFS	Median	All	0.786	0.929	<.001	141	view →
UVM	DFS	Median	All	0.778	0.408	<.001	105	view →
LUAD	DFS	Quartile	All	0.577	0.749	<.001	96	view →
ACC	OS	Median	All	0.368	0.775	<.001	79	view →
UCEC	OS	Median	All	0.781	0.574	.001	54	view →
SKCM	OS	Quartile	All	0.226	0.403	.003	30	view →
LUSC	OS	Median	III,IV	0.389	0.899	.001	27	view →
THCA	OS	Median	IV	0.575	0.939	.005	22	view →
LIHC	DFS	Quartile	All	0.297	0.487	.002	22	view →
ESCA	DFS	Quartile	II,III,IV	1.000	0.246	.020	12	view →
THYM	DFS	Quartile	All	1.000	0.679	.019	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TFAP2A-AS1–KIRC (DFS)

Open the KIRC breakdown →