TFAP2A-AS1

Across TCGA pan-cancer cohorts, TFAP2A-AS1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of TFAP2A-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TFAP2A-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TFAP2A-AS1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

COAD, KIRC, and LUSC are the cancer types where TFAP2A-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TFAP2A-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	+1.227	<.001	11	view →
KIRC	Male	II,III,IV	−0.476	<.001	10	view →
LUSC	Female	All	+1.542	<.001	8	view →
BLCA	All	All	+1.093	<.001	8	view →
LUAD	Female	All	+0.760	<.001	8	view →
STAD	All	II,III,IV	+0.615	<.001	8	view →
KICH	All	All	−0.591	<.001	8	view →
HNSC	Male	All	+0.414	<.001	8	view →
LIHC	All	All	+0.393	<.001	7	view →
UCEC	All	All	+1.775	<.001	6	view →
BRCA	All	II,III,IV	+0.630	<.001	6	view →
READ	Male	All	+1.096	.008	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

TFAP2A-AS1–COAD

Open the COAD breakdown →