TF

Across TCGA patient cohorts, TF mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TF-associated genes across cancer lineages are p62 Lck ligand, ATM, and MEK1. Each is linked with TF in more than 2 cancer types. Because this analysis shows association rather than direction, both TF-to-partner and partner-to-TF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by TF-low versus TF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TF→partner) and Y-score (partner→TF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.405	+3.906	<.001	<.001	3	3
UCEC	ATM →	-0.472	-1.662	.003	.011	3	3
UCEC	MEK1 →	+0.470	+3.807	<.001	<.001	3	2
SKCM	PRDX1 →	+0.211	+3.000	.049	.034	3	2
COAD	HSP70 →	+0.690	+2.820	.009	.035	3	2
COAD	PDCD4 →	-0.539	-3.000	.006	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

p62 Lck ligand by TF expression — UCEC

Explore this box plot interactively →