TF

Across TCGA pan-cancer cohorts, TF RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TF’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TF RNA is repressed in tumor relative to normal tissue. In most cancer types TF is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, COAD, and THCA are the cancer types where TF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	−2.832	<.001	12	view →
COAD	Male	II,III,IV	−0.484	<.001	8	view →
THCA	All	All	−0.266	<.001	8	view →
BRCA	All	III,IV	−3.435	<.001	6	view →
KICH	Female	II,III,IV	−0.222	<.001	6	view →
CHOL	Female	All	−10.180	<.001	5	view →
LIHC	All	All	−0.925	.005	5	view →
LUAD	Female	All	+0.789	.001	4	view →
KIRP	All	All	−0.272	.013	4	view →
ESCA	All	All	−1.316	.027	2	view →
PRAD	All	All	−0.496	.027	2	view →
KIRC	Male	All	+0.448	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TF–HNSC

Open the HNSC breakdown →