TF

Across TCGA cell cohorts, TF mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TF-associated genes across cancer lineages are LALBA, GP9, and WDR87. Each is linked with TF in more than 1 cancer types. Because this analysis shows association rather than direction, both TF-to-partner and partner-to-TF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LALBA grouped by TF-low versus TF-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TF→partner) and Y-score (partner→TF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	LALBA →	+0.047	+4.977	<.001	.007	3	1
LARGE_INTESTINE	GP9 →	+0.073	+3.196	.003	.007	3	1
LARGE_INTESTINE	WDR87 →	+0.030	+4.353	<.001	.001	3	1
LARGE_INTESTINE	OR10W1 →	+0.012	+3.977	<.001	.001	3	1
BLOOD_Leukemia	C20orf85 →	+0.036	+4.969	<.001	.003	3	1
BLOOD_Leukemia	IL22 →	+0.037	+5.569	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

LALBA by TF expression — SKIN

Explore this box plot interactively →