Across TCGA patient cohorts, TEX45 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEX45-associated genes across cancer lineages are VHL, EGFR, and Shc_pY317. Each is linked with TEX45 in more than 1 cancer types. Because this analysis shows association rather than direction, both TEX45-to-partner and partner-to-TEX45 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEX45→partner) and Y-score (partner→TEX45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.992	-3.000	.011	.036	3	1
UCEC	EGFR →	-0.186	-3.000	.044	.037	2	1
UCEC	Shc_pY317 →	-0.231	-3.000	.008	.037	1	1
UCEC	STAT5a →	+0.545	+3.000	.018	.037	1	1
UCEC	Caspase-7-cleavedD198 →	+1.003	+3.000	.003	.037	1	1
UCEC	C-Raf →	+0.172	+3.000	.038	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

TEX45 survival (RNA) · tumor vs normal (RNA) · all TEX45 data types