TEX35

Across TCGA patient cohorts, TEX35 mutation is significantly associated with the RNA expression of many other genes, with 5,468 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEX35-associated genes across cancer lineages are RAD23A, PACS2, and LYNX1. Each is linked with TEX35 in more than 1 cancer types. Because this analysis shows association rather than direction, both TEX35-to-partner and partner-to-TEX35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD23A grouped by TEX35-low versus TEX35-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEX35→partner) and Y-score (partner→TEX35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAD23A →	+0.396	+2.021	.003	<.001	3	2
UCEC	PACS2 →	+0.313	+2.032	.003	.005	3	2
UCEC	LYNX1 →	-0.777	-1.968	.008	.009	3	2
UCEC	MEX3D →	+0.799	+2.343	<.001	<.001	3	2
UCEC	GLRX5 →	+0.428	+2.732	<.001	<.001	3	2
UCEC	RPL23AP82 →	+0.558	+4.868	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,468 associations by consensus.

RAD23A by TEX35 expression — UCEC

Explore this box plot interactively →