TEX2

Across TCGA cell cohorts, TEX2 mutation is significantly associated with the mutation status of many other genes, with 4,954 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TEX2-associated genes across cancer lineages are ITSN1, GPATCH1, and MTHFR. Each is linked with TEX2 in more than 5 cancer types. Because this analysis shows association rather than direction, both TEX2-to-partner and partner-to-TEX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITSN1 grouped by TEX2-low versus TEX2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEX2→partner) and Y-score (partner→TEX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ITSN1 →	+4.053	+4.659	<.001	<.001	1	6
SKIN	GPATCH1 →	+5.053	+4.239	.007	.007	1	5
UPPER_AERODIGESTIVE_TRACT	MTHFR →	+4.442	+3.217	.004	.004	1	5
OVARY	BICRA →	+2.977	+4.273	.006	.006	1	5
LUNG_SCLC	SRRT →	+5.066	+4.502	.007	.007	1	5
OVARY	KIF13B →	+3.562	+4.684	.002	.002	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,954 associations by consensus.

ITSN1 by TEX2 expression — BLOOD_Lymphoma

Explore this box plot interactively →