TEX15

Across TCGA patient cohorts, TEX15 mutation is significantly associated with the total protein of many other genes, with 98 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEX15-associated genes across cancer lineages are mTOR_pS2448, Cyclin-B1, and GAPDH. Each is linked with TEX15 in more than 4 cancer types. Because this analysis shows association rather than direction, both TEX15-to-partner and partner-to-TEX15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by TEX15-low versus TEX15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEX15→partner) and Y-score (partner→TEX15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.075	-0.927	.036	.042	3	5
UCEC	Cyclin-B1 →	+0.579	+1.519	<.001	<.001	3	4
BRCA	GAPDH →	+0.986	+3.169	<.001	.020	3	4
COAD	ASNS →	+0.522	+2.321	<.001	.005	3	4
UCEC	ATM →	-0.430	-2.045	<.001	<.001	3	4
LUAD	ACVRL1 →	-0.096	-1.648	.035	.041	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 98 associations by consensus.

mTOR_pS2448 by TEX15 expression — UCEC

Explore this box plot interactively →