TEX14

Across TCGA patient cohorts, TEX14 mutation is significantly associated with the RNA expression of many other genes, with 5,184 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEX14-associated genes across cancer lineages are FEN1, THOC5, and PSMD9. Each is linked with TEX14 in more than 3 cancer types. Because this analysis shows association rather than direction, both TEX14-to-partner and partner-to-TEX14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FEN1 grouped by TEX14-low versus TEX14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEX14→partner) and Y-score (partner→TEX14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FEN1 →	+0.572	+2.534	<.001	<.001	3	4
LUAD	THOC5 →	+0.507	+2.819	<.001	.001	3	4
COAD	PSMD9 →	+0.360	+2.468	<.001	.001	3	4
LUAD	PSMC3IP →	+0.637	+3.459	<.001	.005	3	4
LUAD	VPS25 →	+0.418	+3.193	.001	.009	3	4
UCEC	SEC13 →	+0.420	+1.584	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,184 associations by consensus.

FEN1 by TEX14 expression — UCEC

Explore this box plot interactively →