Across TCGA cell cohorts, TET3 mutation is significantly associated with the RNA expression of many other genes, with 553 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TET3-associated genes across cancer lineages are GPR63, OR1L8, and C17orf98. Each is linked with TET3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TET3-to-partner and partner-to-TET3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TET3→partner) and Y-score (partner→TET3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GPR63 →	+1.116	+3.489	<.001	.001	3	3
OVARY	OR1L8 →	+0.057	+3.309	<.001	.006	3	2
LARGE_INTESTINE	C17orf98 →	+0.049	+1.793	<.001	.002	3	2
BLOOD_Leukemia	OR4E1 →	+0.186	+2.684	<.001	.004	3	2
LARGE_INTESTINE	ODF2 →	+0.539	+1.850	.001	.006	3	2
LARGE_INTESTINE	GID4 →	+0.436	+3.067	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 553 associations by consensus.

Exploration

TET3 survival (RNA) · tumor vs normal (RNA) · all TET3 data types