TESMIN

Across TCGA patient cohorts, TESMIN mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TESMIN-associated genes across cancer lineages are Caspase-7-cleavedD198, Rad50, and Cyclin-B1. Each is linked with TESMIN in more than 2 cancer types. Because this analysis shows association rather than direction, both TESMIN-to-partner and partner-to-TESMIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TESMIN-low versus TESMIN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TESMIN→partner) and Y-score (partner→TESMIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.548	+1.874	.021	.049	3	3
UCEC	Rad50 →	-0.245	-3.308	.012	.009	3	2
UCEC	Cyclin-B1 →	+0.602	+2.415	.007	.003	3	2
UCEC	FASN →	+0.335	+2.584	.034	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.112	-1.990	.025	.030	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.546	+2.415	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Caspase-7-cleavedD198 by TESMIN expression — UCEC

Explore this box plot interactively →