TESMIN

Across TCGA pan-cancer cohorts, TESMIN RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of TESMIN’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where TESMIN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TESMIN is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

LUAD, KIRC, and COAD are the cancer types where TESMIN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TESMIN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	+2.545	<.001	11	view →
KIRC	Male	II,III,IV	−0.821	<.001	11	view →
COAD	Female	All	+0.793	<.001	9	view →
LUSC	Female	All	+2.391	<.001	8	view →
STAD	Female	All	+1.957	<.001	8	view →
BLCA	Male	All	+1.480	<.001	8	view →
LIHC	Female	All	+0.836	<.001	8	view →
HNSC	Male	All	+0.827	<.001	8	view →
KIRP	Male	III,IV	−0.942	<.001	7	view →
BRCA	All	III,IV	+1.807	<.001	6	view →
UCEC	All	All	+1.630	<.001	6	view →
THCA	Male	All	−0.451	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

TESMIN–LUAD

Open the LUAD breakdown →