TESMIN

Across TCGA cell cohorts, TESMIN mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TESMIN-associated genes across cancer lineages are OR2M5, IQCF6, and KRTAP13-4. Each is linked with TESMIN in more than 1 cancer types. Because this analysis shows association rather than direction, both TESMIN-to-partner and partner-to-TESMIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2M5 grouped by TESMIN-low versus TESMIN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TESMIN→partner) and Y-score (partner→TESMIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2M5 →	+0.016	+4.415	<.001	.007	3	1
LARGE_INTESTINE	IQCF6 →	+0.311	+4.467	<.001	.004	3	1
OVARY	KRTAP13-4 →	+0.028	+4.222	<.001	.006	3	1
LUNG_NSCLC_LUAD	P2RY13 →	+0.019	+4.727	<.001	<.001	3	1
BLOOD_Leukemia	ZP2 →	+0.179	+4.409	<.001	.005	3	1
BLOOD_Leukemia	ZIC3 →	+0.019	+5.060	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

OR2M5 by TESMIN expression — LARGE_INTESTINE

Explore this box plot interactively →